Wake Forest University School of Medicine Division Home
Employee Login
PHS Contacts
Site Map
PHS:  Distinctive in Research Excellence PHS:  Distinctive in Research Excellence
  Quick Links:
 
Departments:
Division Administration
Biostatistical Sciences
Epidemiology & Prevention
Social Sciences & Health Policy
People:
All Faculty & Staff
infiNet Directory (Internal Only)
Faculty
Biostatisticians
Programmers & Network Admins
Project Managers
PHS Highlights:
 Genetic Software Downloads
 SNPDOC Search
 Statistical Power Calculators
PHS SeminarsSeminar Calendars

PHS General Events
No upcoming events.

Biostatistical Series
Andrea (Ruggiero) Anderson, Biostatistician IV
"Results From The Rural Nutrition and Oral Health Study (RUN-OH)"

Journal Club Series
No upcoming events.

Programmers User Group
No upcoming events.

Research Series
Robert P. (Bob) Schwartz, M.D.
"YMCA Healthy, Fit and Strong Program" and "BMI Squared: Brief Motivational Interviewing to Reduce Child Body Mass Index"
RISU Seminars
No upcoming events.
 

PHS Division Directory 

Carl D Langefeld , Ph.D.
Section Head

Langefeld, Carl D
Statistical Genetics & Bioinformatics
Department of Biostatistical Sciences
Division of Public Health Sciences
Wake Forest University Health Sciences

Admin Assistant/Secretary: Rhonda Hawks
Wachovia (WC)
Room Number: 2321
Medical Center Blvd.
Winston-Salem, North Carolina 27157-1063

Telephone: 336-713-0013
Email: clangefe@wfubmc.edu

EDUCATION:
B.S. (Biology/Mathematics) Concordia University, Seward, Nebraska
B.A. (Education) Concordia University, Seward, Nebraska
M.S. (Ecology, Systematics and Evolutionary Biology), University of Nebraska-Lincoln, Lincoln, NE
M.S. (Applied Statistics) The Florida State University, Tallahassee, FL Ph.D. (Biostatistics) University of Michigan, Ann Arbor, MI 

RESEARCH:
Dr. Langefeld is a statistical geneticist whose research focuses on the mapping of complex genetic traits. Such traits are familial, but their inheritance patterns appear to differ from simple Mendelian inheritance due to incomplete penetrance, sporadic cases, genetic heterogeneity, epistasis and gene-environment interactions. Thus, the magnitude of the genetic effect may be modest or masked by the complexity of the etiologic mechanism. The ultimate goal of this research is to assist in the isolation and cloning of disease-predisposing genes for the prevention and treatment of the disease.

Dr. Langefeld’s methodological research focuses on the development of association and linkage methods for the mapping of complex genetic traits. He has developed a class of regression-based tests for linkage asymptotically equivalent to the class of nonparametric linkage (NPL) tests developed by Whittemore and Halpern (1994; Langefeld and Boehnke 1999, Langefeld et al., In Press). The primary advantage of NPL regression is that it allows one to simultaneously evaluate the effects of multiple loci, their interactions and their interactions with environmental factors or other phenotypic characteristics. In collaboration with Cralen Davis, he has developed an extension of regression diagnostic methods that can assist in the identification of pedigrees who disproportionately contribute evidence for linkage at a particular locus or loci, or for whom a proposed model does not fit (Davis et al., In Press). In collaboration with Dr. Michael Boehnke (University of Michigan) and Dr. Linda Green (Wake Forest University, Department of Public Health Sciences),he has developed a test for linkage disequilibrium, the discordant alleles test (DAT), for when parental data are not available (Boehnke and Langefeld (1998). In addition to statistical genetics, he maintains a broad interest in biostatistics and, in particular, longitudinal data analysis and model validation (Miller et al., 1993, 1996). Dr. Langefeld was a finalist for the 2000 James V.Neel Young Investigator Award of the International Society of Genetic Epidemiology.

Dr. Langefeld has a strong interest in diabetes (type 1, type 2 andgestational) and its complications. He is a co-investigator onNIH-funded grants for type 2 diabetes (IRAS Family Study: Geneticsof Insulin Resistance, Mapping Genes for NIDDM Nephropathy inAfrican Americans) and systemic lupus erythematosus SpecializedCenter of Research (SCOR) in Systemic Lupus, Gene Mapping inSystemic Lupus Erythematosus), end-stage renal disease (Genetic Analysis of Human Hypertensive ESRD) and asthma (CollaborateStudies on the Genetics of Asthma). Dr. Langefeld is also involved inthe Finland-United States Investigation of Non- Insulin-DependentDiabetes Mellitus (FUSION) Study.
 

PUBLICATIONS (10 most recent):
View all publications for this profile>>

Divers J;Wagenknecht LE;Bowden DW;Carr JJ;Hightower RC;Xu J;Langefeld CD;Freedman BI;  Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study; Diabetes Care; 2010 Jan; 33:131-138
Palmer ND;Langefeld CD;Ziegler JT;Hsu F;Haffner SM;Fingerlin T;Norris JM;Chen YI;Rich SS;Haritunians T;Taylor KD;Bergman RN;Rotter JI;Bowden DW;  Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study; Diabetologia; 2010 Feb; 53:281-289
Divers J;Sale MM;Lu L;Chen WM;Lok KH;Spruil IJ;Fernandes JK;Langefeld CD;Garvey WT;  The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The sea islands genetic African American registry (project SuGAR); J Lipid Res ; 2009 Sep 25;
Young KA;Engelman CD;Langefeld CD;Hairston KG;Haffner SM;Bryer-Ash M;Norris JM;  Association of plasma vitamin D levels with adiposity in Hispanic and African Americans; J Clin Endocrinol Metab; 2009 Sep; 94:3306-3313
Miller DJ;Zhang Y;Yu G;Liu Y;Chen L;Langefeld CD;Herrington D;Wang Y;  An algorithm for learning maximum entropy probability models of disease risk that efficiently searches and sparingly encodes multilocus genomic interactions; Bioinformatics ; 2009 Oct 1; 25:2478-2485
Miller MR;Zhang W;Sibbel SP;Langefeld CD;Bowden DW;Haffner SM;Bergman RN;Norris JM;Fingerlin TE;  Variant in the 3' Region of the IkappaBalpha Gene Associated With Insulin Resistance in Hispanic Americans: The IRAS Family Study; Obesity (Silver Spring); 2009 Oct 1;
Freedman BI;Bowden DW;Ziegler JT;Langefeld CD;Lehtinen AB;Rudock ME;Lenchik L;Hruska KA;Register TC;Carr JJ;  Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study; J Bone Miner Res ; 2009 Oct; 24:1719-1727
Norris JM;Langefeld CD;Talbert ME;Wing MR;Haritunians T;Fingerlin TE;Hanley AJ;Ziegler JT;Taylor KD;Haffner SM;Chen YD;Bowden DW;Wagenknecht LE;  Genome-wide Association Study and Follow-up Analysis of Adiposity Traits in Hispanic Americans: The IRAS Family Study; Obesity (Silver Spring); 2009 Oct; 17:1932-1941
Freedman BI;Hicks PJ;Bostrom MA;Comeau ME;Divers J;Bleyer AJ;Kopp JB;Winkler CA;Nelson GW;Langefeld CD;Bowden DW;  Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD; Nephrol Dial Transplant ; 2009 Nov; 24:3366-3371
Harley IT;Kaufman KM;Langefeld CD;Harley JB;Kelly JA;  Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies; Nat Rev Genet ; 2009 May; 10:285-290

  How to update your website profile and publications >>
 
PHS Hot Topics
   

Psychiatry Grand Rounds
2010 Schedule >>

Translational Science Inst
Programs >>
Seminar Series >>
Education >>
Research Resources >>

WFUHS Training
Training and development events calendar (Internal Use Only) >>

Piedmont Triad Research Park
Read More >>

Recent Publications:

The Effect of Randomization to Weight Loss on Total Mortality in Older Overweight and Obese Adults: The ADAPT Study

J Gerontol A Biol Sci Med Sci , 2010 Jan 15,
Shea MK;Houston DK;Nicklas BJ;Messier SP;Davis CC;Miller ME;Harris TB;Kitzman DW;Kennedy K;Kritchevsky SB;

Read More >>

Wake Forest Univeristy Baptist Medical Center